Potawatomi Bingo Casino is one of the largest Indian casinos in the U.twinrivers casino reviews WISCONSIN ONLINE GAMBLING Potawatomi Hotel & Casino is located in Milwaukee and open 24 hours. It’s one of the country’s largest tribally owned and operated casinos. Home United States casinos Wisconsin casinos Milwaukee casinos Potawatomi Hotel & Casino. Website. Casino hours. Open 24/7. Poker. Potawatomi Hotel & Casino. Player's Club. Events Calendar. Milwaukee's Biggest Happy Hour ». JUNE Slot Jackpot Winners.